Clinical and prognostic significance of genetic markers in craniocerebral injury (Part III).

It is now becoming increasingly clear that the course and outcome of craniocerebral injury (CCI) are determined not only by its biomechanism, severity, patient's age, presence of premorbid factors, etc., but also by individual features of the genome of each patient, which puts traumatic brain injury among multifactorial diseases. The genome determines the presence or absence of«genetic predilection to the development of various complications and sequelae of CCI, which generally determines the progression of traumatic brain injury disease.

[The structure of hospital morbidity and enhancement of medical care in neurosurgery department].

The article presents analysis of structure of hospital morbidity and indicators of activities of neurosurgery department of the Republic clinical hospital of emergency care of the Chechen Republic. The analysis date supports increasing quality of curative diagnostic processes and valuable development of algorithm of provision of medical care of this profile in curative preventive institution.

[Analysis of thyroid homeostasis disorders in patients with severe traumatic brain injury].

Aim of the study was to investigate the status of thyroid homeostasis and the relationship between severe traumatic brain injury (TBI) and thyroid disorders. The study included 56 patients. Protocol of the study concluded: noninvasive and invasive hemodynamic monitoring, including PICCO, transcranial Doppler ultrasonography, measurement of intracranial pressure (ICP), indirect calorimetry, levels of thyroid stimulating hormone (TSH), T3, T4 and free fractions.

[Clinical and prognostic value of inflammatory genetic markers in traumatic brain injury].

The paper analyses the published data about association of polymorphic gene markers of different bioactive agents (interleukins, angiotensin convertase, catechol-O-methyltransferase, dopamine receptors etc.) with traumatic brain injury. Analysis of the entire pool of data concerning clinical and experimental studies of association of different polymorphic markers of candidate genes with outcome of traumatic brain injury allows to conclude that IL 1alpha and IL 1beta, IL 6, catechol-O-methyltransferase, angiotensin convertase, D2 dopamine receptors in fact play important role in neuroinflammatory response to injury and recovery of the brain ant its functions.

[Population health in the Chechen Republic].

The activities of health care system and indicators of population health are analyzed in the Chechen Republic which undergoes chain of social disasters during last twenty years. The study used data of official statistical documents from various departments and author's immediate observation of events under study. The conclusions are made that serious problems exist in the health conditions of population in the Republic despite relatively safe official statistic indicators.