YouTube User Traffic to Paired Epilepsy Education Videos in English and Spanish: Comparative Study.

Background: Effectively managing epilepsy in children necessitates the active engagement of parents, a factor that is reliant on their understanding of this neurological disorder. Widely available, high-quality, patient-focused, bilingual videos describing topics important for managing epilepsy are limited. YouTube Analytics is a helpful resource for gaining insights into how users of differing backgrounds consume video content.

Cardiac ischemia/reperfusion increases cardiomyocyte KLF5 in pigs and mice that aggravates tissue injury and remodeling.

Aims: Activation of the transcriptional factor Krüppel-like factor 5 (KLF5) is detrimental to chronic heart failure. We explored the involvement of KLF5 in myocardial ischemia/reperfusion injury.

Methods And Results: Yorkshire pigs underwent 75΄ of ischemia, followed by 3h or 24h of reperfusion.

Quantifying joystick interactions and movement patterns of toddlers with disabilities using powered mobility with an instrumented Explorer Mini.

Powered mobility technology can be a powerful tool to facilitate self-initiated exploration and play for toddlers with motor disabilities. The joystick-controlled Permobil Explorer Mini is currently the only commercially available powered mobility device for children ages 1-3 years in the United States. However, many open questions persist regarding how joystick-based mobility technologies should be designed to optimally suit the developmental needs of toddlers.

Recombinant factor VIIa: new insights into the mechanism of action through product innovation.

Management of bleeding in persons with hemophilia and inhibitors involves treatment with bypassing agents, including recombinant activated factor VII (rFVIIa). Two rFVIIa products are commercially approved for use in the United States and the European Union. Eptacog alfa and eptacog beta share the same amino acid sequence but differ in posttranslational modifications.

Alcohol drinking is associated with greater calcium activity in mouse central amygdala dynorphin-expressing neurons.

Unlabelled: Alcohol use disorder (AUD) is a chronic disease that poses significant economic burden and health risks. It is pivotal to better understand brain mechanisms engaged by alcohol that promote misuse. The central amygdala (CeA) has emerged as a key mediator of excessive preclinical alcohol consumption.