Publications by authors named "M P Grisham"
The objective of this study was to determine how housing temperature and genetic diversity affect the onset and severity of allogeneic T cell-induced tissue damage in mice subjected to reduced intensity conditioning (RIC). We found that adoptive transfer of allogeneic CD4 T cells from inbred donors into sub-lethally irradiated inbred recipients (I→I) housed at standard housing temperatures (ST; 22-24 °C) induced extensive BM and spleen damage in the absence of injury to any other tissue. Although engraftment of T cells in RIC-treated mice housed at their thermo-neutral temperature (TNT; 30-32 °C) also developed similar BM and spleen damage, their survival was markedly and significantly increased when compared to their ST counterparts.
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- This study identifies 16 catalase (CAT) genes in the sugarcane plant Saccharum spontaneum, which are important for managing reactive oxygen species (ROS) and regulating plant growth and development.
- The identified SsCAT genes are grouped into three subfamilies, showing similar structures and functional patterns, with most containing key conserved elements for their activity.
- The research also reveals that these genes are differentially expressed under various stresses and in different tissues, indicating their potential role in enhancing stress resistance in sugarcane when overexpressed, particularly ScCAT1 which helps manage pathogen infections.
Article Synopsis
- A study was conducted on sugarcane smut, a severe fungal disease, by crossing a smut-resistant variety (YT93-159) with a susceptible one (ROC22) to analyze the genetic basis of resistance through their progenies.
- The analysis identified over 2.3 million Single Nucleotide Polymorphisms (SNPs) and more than 7,295 differentially expressed genes linked to resistance pathways, focusing on stress-related metabolism and hormonal signaling.
- Key findings highlighted a specific region on chromosome Chr5B with 129 candidate genes, including 24 important for stress response, leading to a proposed molecular mechanism for smut resistance in sugarcane and offering markers for future breeding efforts.
The SARS-CoV-2 pandemic provides a natural opportunity for the collision of coronavirus disease-2019 (COVID-19) with chronic infections, which place numerous individuals at high risk of severe COVID-19. Infection with Human Immunodeficiency Virus (HIV), a global epidemic, remains a major public health concern. Whether prior HIV+ status exacerbates COVID-19 warrants investigation.
View Article and Find Full Text PDFSugarcane smut is a major fungal disease caused by , which seriously reduces the yield and quality of sugarcane. In this study, 36 transcriptome data were collected from two sugarcane genotypes, YT93-159 (resistant) and ROC22 (susceptible) upon infection. Data analysis revealed 20,273 (12,659 up-regulated and 7614 down-regulated) and 11,897 (7806 up-regulated and 4091 down-regulated) differentially expressed genes (DEGs) in YT93-159 and ROC22, respectively.
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