Publications by authors named "M P Glode"
Article Synopsis
- Patients with prostate cancer experience significant sexual dysfunction following treatment, impacting their mental health and relationships.
- An international panel created guidelines to help clinicians and patients understand the effects of prostate cancer treatments on sexual health and relationships, emphasizing the importance of biopsychosocial rehabilitation for survivors.
- The guidelines were developed through a systematic literature review, considering cultural diversity and the unique needs of various sexual orientations and gender identities, aimed at fostering open discussions about sexual health outcomes.
Background: Kawasaki Disease (KD) is an acute vasculitis of unknown etiology in children that can lead to coronary artery lesions (CAL) in 25% of untreated patients. There is currently no diagnostic test for KD, and the clinical presentation is often difficult to differentiate from other febrile childhood illnesses. Circulating microRNAs (miRNAs) are small noncoding RNA molecules that control gene expression by inducing transcript degradation or by blocking translation.
View Article and Find Full Text PDFObjectives: To determine the safety, tolerability, pharmacokinetics, and immunomodulatory effects of a 6-week course of atorvastatin in patients with acute Kawasaki disease with coronary artery (CA) aneurysm (CAA).
Study Design: This was a Phase I/IIa 2-center dose-escalation study of atorvastatin (0.125-0.
Objective: To evaluate variations in treatment practice and compliance with national guidelines for the diagnostic evaluation of children with Kawasaki disease (KD).
Study Design: We used the Pediatric Hospital Information System database to analyze demographic, laboratory and treatment data from patients admitted with KD between January 1, 2006, and December 31, 2015.
Results: During the study period, 12,089 children with KD were diagnosed.
Article Synopsis
- There is currently no diagnostic test for Kawasaki disease (KD), leading to potential delays in treatment and increased risk of serious complications like coronary artery aneurysms.
- The objective of the study was to identify a gene expression signature in whole blood that could differentiate children with KD in their early illness (first week) from those with other febrile conditions.
- The research involved a diverse group of 404 children for discovery testing, and a separate validation group showed promising results in using gene expression patterns to effectively distinguish KD from other infections and inflammatory diseases.