Publications by authors named "M P Georgiadis"
Reduction-oxidation factor-1 or apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) is a crucial redox-sensitive activator of transcription factors such as NF-κB, HIF-1α, STAT-3 and others. It could contribute to key features of ocular neovascularization including inflammation and angiogenesis; these underlie diseases like neovascular age-related macular degeneration (nAMD). We previously revealed a role for Ref-1 in the growth of ocular endothelial cells and in choroidal neovascularization (CNV).
View Article and Find Full Text PDFArticle Synopsis
- Olfactory dysfunction may signal early stages of Alzheimer's disease (AD), prompting research into the piriform cortex using tau PET-MR imaging.
- A study of 94 older adults revealed increased tau uptake in the piriform cortex correlating with disease severity, particularly in those with Alzheimer’s compared to amyloid-negative controls.
- The results indicate heightened tau levels in AD and mild cognitive impairment, connecting greater piriform uptake with poorer memory performance, while no significant changes were observed in cognitively unimpaired Parkinson's disease.
Article Synopsis
- SRY (Sex-determining Region Y) is a key transcription factor in male embryonic development, initiating male characteristics in therian mammals through specific DNA interactions.
- SRY binds tightly to DNA at a consensus site, forming numerous hydrogen bonds that induce sharp bends in the DNA, which are crucial for its function.
- Substitutions in specific amino acids of the SRY protein affect its ability to bind DNA and activate target genes, indicating that these interactions are vital for proper male development.
EFSA requested its Scientific Committee to prepare a guidance document on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments. The guidance document provides an introduction to epidemiological studies and illustrates the typical biases, which may be present in different epidemiological study designs. It then describes key epidemiological concepts relevant for evidence appraisal.
View Article and Find Full Text PDF2-Arachidonoyl glycerol (2-AG) is the principal endogenously produced ligand for the cannabinoid CB1 and CB2 receptors (CBRs). The lack of potent and efficacious 2-AG ligands with resistance against metabolizing enzymes represents a significant void in the armamentarium of research tools available for studying eCB system molecular constituents and their function. Herein we report the first endocannabinoid glyceride templates with remarkably high potency and efficacy at CBRs.
View Article and Find Full Text PDF