Differential responses to chronic hypoxia and dietary restriction of aerobic capacity and enzyme levels in the rat myocardium.

Chronic exposure of mammals to hypoxia induces a state of anorexia. We aimed to determine the role played by diet restriction in the alterations of myocardial energy metabolism occurring under chronic hypoxia in order to detect the specific effects of hypoxia per se. Adult female rats were exposed to normobaric hypoxia (FiO2 = 0.