Obesity and Childhood Leukemia in Brazil: Biological, Regional, and Environmental Insights.

This mini-review aimed to present an outlook on childhood obesity and leukemia in different regions of Brazil and explore a possible association between biological aspects related to adipose tissue and childhood cancer. We emphasized environmental factors that may influence cancer development and obesity and present studies showing different prevalences of these diseases in Brazilian regions. However, future studies are required to determine how environmental factors in these regions contribute to leukemia and obesity development in childhood and adolescence.

A Portuguese expert panel position paper on the management of heart failure with preserved ejection fraction - Part II: Unmet needs and organization of care in Portugal.

In Portugal, a 15.2% prevalence of heart failure with preserved ejection fraction (HFpEF) was recently identified among those aged ≥50 years. HFpEF represents 90% of Portuguese heart failure patients.

Targeting the PDK/PDH axis modulates neutrophil and smooth muscle cell pathological responses and prevents abdominal aortic aneurysm formation.

Aims: Abdominal aortic aneurysm (AAA) is a life-threatening condition where inflammation plays a key role. Currently, AAA treatment relies exclusively on surgical interventions, and no guideline drug therapy to prevent aneurysm growth or rupture is available. Pharmacological reprogramming of immune cell metabolism, through the modulation of the pyruvate dehydrogenase kinase/pyruvate dehydrogenase (PDK/PDH) axis, has been identified as an attractive strategy to combat inflammation.

Extraction and Purification of the FrHb1 Fraction from Commercial Natural Latex of for Biomedical Applications.

Biomaterials interact with biological systems, influencing their responses. Different types of polymers-both natural and synthetic-are widely used in biomedical engineering, among a plethora of healthcare applications, to promote tissue regeneration. The natural rubber latex extracted from is a biopolymer that whose biocompatibility makes it a valuable study object.

Tropis needle-free injector for fractional-dose IPV administration: A pilot study for integration into routine immunization services in Cuba.

Fractional-dose inactivated poliovirus vaccine (fIPV), 1/5th of a standard IPV dose, is used in Cuba's routine immunization (RI) schedule. Tropis, a needle-free jet injector, simplifies intradermal fIPV administration and was piloted in Camagüey, Cuba, from 2019 to 2020. This study assessed Tropis' acceptability, safety, and immunogenicity compared to traditional needle and syringe (N/S) administration.