Publications by authors named "M P Felice"
Activity budget investigations are necessary to understand how individuals within a group manage their daily activities, thus providing insights into the social dynamics of a species. Our objective was to explore and describe the behavioral activities within a group of managed care killer whales. From 261hours of coded surface video collected from April 2022 to January 2023, we scan-sampled day-time hours to examine eight behavioral categories exhibited by 8-9 killer whales bimonthly.
View Article and Find Full Text PDFHigh-dose methotrexate is an effective and safe therapy. It is included in the treatment regimens of various hematologic and oncologic diseases. The acute and severe toxicity of this chemotherapeutic agent is unusual.
View Article and Find Full Text PDFArticle Synopsis
- - Gastric cancer (GC) is a complex and aggressive type of cancer that starts in the stomach and can spread to other organs, often becoming deadly by stage IV.
- - The study analyzed gene expression data from 719 patients to identify a specific gene signature linked to the progression from stage I to stage IV GC, focusing on factors like ECM organization and epithelial-to-mesenchymal transition (EMT).
- - The findings suggest that this gene signature could help identify stage I patients at higher risk of progression, potentially aiding in early treatment strategies, while also providing a new experimental model to study how gastric cancer spreads.
Protein folding and unfolding experiments are interpreted under the assumption of microscopic reversibility, that is, that at equilibrium one process is the reverse of the other. Single-domain proteins illustrate the validity of such an interpretation, although reversibility does not necessarily hold under the different conditions typically used for folding and unfolding experiments. In fact, more complex proteins, which often exhibit irreversible unfolding, are generally considered not amenable to folding kinetics studies.
View Article and Find Full Text PDFArticle Synopsis
- Continuous active sonar produces lower sound pressure levels compared to traditional pulsed active sonar but can cause higher auditory masking due to its constant operation.
- The study evaluates how different noise types, including continuous active sonar, affect signal detection in killer whales using both a pure tone and a whale call.
- Results show that while other noise types allowed for some frequency detection, continuous active sonar significantly overlaps with killer whale calls, making it a strong auditory masker.*