Real-world demographic and clinical profiles of patients with treatment-resistant depression initiated on esketamine nasal spray.

Objective: ESKALE is a French, multicentre, observational study of adults with treatment-resistant depression (TRD) treated with esketamine. This interim analysis describes baseline demographic and clinical characteristic evolution in patients included and treated from early access program to post-marketing launch.

Methods: Data were collected from medical records and included patient characteristics, disease history at esketamine initiation, use of neurostimulation, the patient's care pathway, and the number of antidepressant treatment lines prescribed prior to esketamine initiation.

Use of hospital big data to optimize and personalize laboratory test interpretation with an application.

Background And Aims: In laboratory medicine, test results are generally interpreted with 95% reference intervals but correlations between laboratory tests are usually ignored. We aimed to use hospital big data to optimize and personalize laboratory data interpretation, focusing on platelet count.

Material And Methods: Laboratory tests were extracted from the hospital database and exploited by an algorithmic stepwise procedure.

Esketamine nasal spray in patients with treatment-resistant depression: the real-world experience in the French cohort early-access programme.

Objective: To present the first real-world data of patients with treatment-resistant depression (TRD) treated with esketamine through a French cohort Temporary Authorisation for Use (ATUc) programme.

Methods: In 2019, the French Health Authorities exceptionally granted the first ATUc in psychiatry for TRD patients. Clinical characteristics, safety and efficacy data were reported by physicians.

The French Cochlear Implant Registry (EPIIC): Cochlear implantation complications.

Objectives: The aim of this study was to evaluate peri- and post-operative complications related to cochlear implantations. We searched for risk factors predicting these complications and analyzed the complications in the youngest and most elderly.

Study Design: Retrospective analysis of cochlear implant patients.

Neck Surgery with Hypnosis: An Evaluation Based Upon Patient's Self Assessment.

Background: Surgery with hypnosis avoids the use of general anesthesia (GA). It also shortens hospitalization and promotes outpatient surgery. The objective of this study has been to assess the satisfaction of operated patients.