Publications by authors named "M P Chiao"
Article Synopsis
- Human induced pluripotent stem cell-derived cardiomyocytes (hiPSCCMs) show great potential as a model for studying heart function, but their immaturity limits their effectiveness.
- This study introduces a micropatterned substrate made from polydimethylsiloxane (PDMS) with varying stiffness to improve hiPSCCM maturation, allowing for better cell alignment and contractility over a three-week culture period.
- Findings indicate that culturing hiPSCCMs on this substrate enhances their maturity, as seen through improved contractility and calcium transient kinetics, making it a valuable tool for future disease modeling and treatment research.
Introduction: Despite the progress in gene editing platforms like CRISPR/Cas9 with the potential to transform the standard of care for haemophilia, the language used to explain and discuss gene editing is not aligned across the haemophilia community. Here, we present the objective and rationale for developing a clear, consistent, and globally aligned gene editing lexicon to address these communication gaps.
Methods: Effectively communicating complex gene editing concepts requires a clear and consistent vocabulary.
Background: Glioblastoma multiforme (GBM) is an aggressive type of brain tumor that is difficult to remove surgically. Research suggests that substances from saffron, namely crocetin and crocin, could be effective natural treatments, showing abilities to kill cancer cells.
Methods: Our study focused on evaluating the effects of crocetin on glioma using the U87 cell line.
Soft pneumatic actuators (SPAs) play a crucial role in generating movements and forces in soft robotic systems. However, existing SPA designs require significant structural modifications to be used in applications other than their original design. The present article proposes an omni-purpose fully 3D-printable SPA design inspired by membrane type mold and cast SPAs.
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- - This study investigated the genetic factors affecting survival duration in Glioblastoma Multiforme (GBM) patients using Next-Generation Sequencing, dividing 30 patients into extended (over two years) and abbreviated (under two years) survival groups.
- - Key mutations identified included CHEK2, IDH1, and TP53, with non-coding variants found in TERT and TP53 RNA splicing sites, although no statistical significance was reached due to the small sample size.
- - Interestingly, TP53 mutations were more common in the longer-surviving group, challenging previous Western findings; however, further research is necessary to explore their functional implications and the role of other mutations in therapeutic strategies.