Publications by authors named "M P Chatrathi"

Article Synopsis
  • Spaceflight presents unique health risks for astronauts, particularly regarding skin health, which are not yet fully understood.
  • A comprehensive analysis using various biological datasets revealed significant changes in skin-related biological processes during spaceflight, including DNA damage and mitochondrial issues.
  • The study's results emphasize the potential for developing strategies to reduce skin damage from space travel and highlight the body's ability to adapt back to Earth's conditions after missions.
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Spaceflight poses a unique set of challenges to humans and the hostile Spaceflight environment can induce a wide range of increased health risks, including dermatological issues. The biology driving the frequency of skin issues in astronauts is currently not well understood. To address this issue, we used a systems biology approach utilizing NASA's Open Science Data Repository (OSDR) on spaceflown murine transcriptomic datasets focused on the skin, biomedical profiles from fifty NASA astronauts, and confirmation via transcriptomic data from JAXA astronauts, the NASA Twins Study, and the first civilian commercial mission, Inspiration4.

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Objective: To document sleep duration and sleep quality among a sample of Marshallese adults and to examine if sleep duration and quality are associated with type 2 diabetes, body mass index (BMI), and self-reported health in the Marshallese population.

Design: Cross-sectional analysis of a staff-administered survey.

Setting: Thirty Marshallese churches in Arkansas and Oklahoma.

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Social networks - or the web of relationships between individuals - may influence cardiovascular disease risk, particularly in low-income urban communities that suffer from a high prevalence of cardiovascular disease. Our objective was to describe the social networks of public housing residents - a low-income urban population - in Baltimore, MD and the association between these networks and blood pressure. We used cross-sectional survey data of randomly selected heads of household in two public housing complexes in Baltimore, MD (8/2014-8/2015).

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We demonstrate here that the electrode kinetics of an electrochemical detector contributes greatly to the resolution of the analyte bands in microchip electrophoresis systems with amperometric detection. The separation performance in terms of resolution and theoretical plate number can be improved and tailored by selecting or modifying the working electrode and/or by controlling the detection potential. Such improvements in the separation performance reflect the influence of the heterogeneous electron-transfer rate of electroactive analytes upon the post-channel band broadening, as illustrated for catechol and hydrazine compounds.

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