Publications by authors named "M P Caligiuri"
Temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) is associated with a complex genetic architecture, but the translation from genetic risk factors to brain vulnerability remains unclear. Here, we examined associations between epilepsy-related polygenic risk scores for HS (PRS-HS) and brain structure in a large sample of neurotypical children, and correlated these signatures with case-control findings in in multicentric cohorts of patients with TLE-HS. Imaging-genetic analyses revealed PRS-related cortical thinning in temporo-parietal and fronto-central regions, strongly anchored to distinct functional and structural network epicentres.
View Article and Find Full Text PDFNKp46 is a critical regulator of natural killer (NK) cell immunity, but its function in non-NK innate immune cells remains unclear. Here, we show that NKp46 is indispensable for expressing IL-2 receptor-α (IL-2Rα) by non-NK liver-resident type-1 innate lymphoid cells (ILC1s). Deletion of NKp46 reduces IL-2Rα on ILC1s by downregulating NF-κB signaling, thus impairing ILC1 proliferation and cytotoxicity in vitro and in vivo.
View Article and Find Full Text PDFArticle Synopsis
- Pediatric-onset Huntington's disease (POHD) shows different symptoms than adult-onset HD (AOHD), primarily presenting with movement disorders like rigidity instead of the chorea seen in AOHD.
- Researchers sought to find specific biomarkers related to the pathophysiology of POHD by using advanced imaging techniques and comprehensive clinical assessments.
- Results indicated that POHD is characterized by more severe striatal volume loss and significant alterations in glucose metabolism across various brain regions compared to AOHD, reinforcing the idea that POHD is a distinct condition with unique biological traits.