Publications by authors named "M P Borrelli"

Hard-to-heal wounds represent a global and growing medical and economic burden. Skin autografting is a useful treatment option but is often limited by donor site morbidity, logistical considerations, and grafting success in compromised wound beds. Combining autologous skin cell suspension (ASCS) technology with minced dermal grafts can allow for dermal elements and epithelial healing as well as closed donor sites.

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Aims: Remodeling of the extracellular matrix (ECM) is critical for effective wound healing and maintaining organ homeostasis. The ECM of soft tissues, including cardiac, contains embedded nanovesicles; or matrix-bound nanovesicles (MBV). The luminal cargo of MBV consists of lipids, microRNAs (miRNAs), and proteins that influence the function of immune and stromal cells.

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(1) Background: Microbial keratitis is a serious eye infection that carries a significant risk of vision loss. spp. are known to cause keratitis and their bacterial endosymbionts can increase virulence and/or treatment resistance and thus significantly worsen the course of the disease.

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Upon detachment from the primary tumour, epithelial ovarian cancer cells can form multicellular aggregates, also referred to as spheroids, that have the capacity to establish metastases at distant sites. These structures exhibit numerous adaptations that may facilitate metastatic transit and promote tumorigenic potential. One such adaptation is the acquisition of dormancy, characterized by decreased proliferation and molecular features of quiescence.

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Article Synopsis
  • The study investigates the long-term clinical outcomes (up to 10 years) of Descemet Membrane Endothelial Keratoplasty (DMEK) and Triple-DMEK procedures in patients with conditions like Fuchs endothelial dystrophy and pseudophakic bullous keratopathy.
  • A total of 54 eyes were followed for at least 5 years, revealing significant improvements in best-corrected visual acuity post-surgery, though endothelial cell density decreased over time, independent of visual acuity.
  • Findings suggest that while endothelial cell density declines, patients maintain good vision for a decade post-surgery, with stable corneal thickness and relatively low rates of graft failure and complications.
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