Publications by authors named "M P Bal"
Null mutations for genes encoding a major seed storage protein in pea, vicilin, were sought through screening a fast-neutron mutant population. Deletion mutations at four or five vicilin loci, where all vicilin genes within each locus were deleted, were combined to address the question of how removal or reduction of a major storage protein and potential allergen might impact the final concentration of protein per unit mature seed weight, seed yield and viability. While the concentration of seed protein was not reduced in mature seeds of mutant lines, indicative of a re-balancing of the proteome, notable differences were apparent in the metabolite, proteomic and amino acid profiles of the seeds, as well as in some functional properties.
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- A growing interest in applying complex systems methods to study socioeconomic inequalities in health is found, but there's a noticeable gap in how these methods are actually utilized in research.
- The analysis reveals that studies employing more complex systems concepts also provide better reporting on relationships within the data, but the underlying beliefs within the system are often overlooked.
- The authors emphasize the need for better reporting practices, including a full depiction of model structures, and suggest creating guidelines to enhance clarity and effectiveness in future studies.
Article Synopsis
- Fine needle aspiration (FNA) is a key method for diagnosing salivary gland lesions, and the modified MSRSGC helps standardize FNA report classifications.
- In a study of 325 patients treated from 2012 to 2019, the sensitivity of the modified MSRSGC was 64.18%, and its specificity was 91.94%.
- The use of frozen sections (FS) primarily aimed to establish a primary diagnosis, mostly showing malignancy when FNA results were classified as type V or higher, indicating that FS may not significantly enhance intraoperative decision-making.
Prenatal exposure to heavy metals such as Lead (Pb), arsenic (As), cadmium (Cd), and selenium (Se) is associated with various adverse pregnancy outcomes. This study examines the association between early pregnancy maternal blood levels of these metals and adverse pregnancy outcomes, while also addressing the differences between low-risk and high-risk groups based on having a history of preterm birth (PTB). This prospective cohort study recruited parous women during first trimester, categorized into low-risk and high-risk groups.
View Article and Find Full Text PDFPseudokinase TRIB2, a member of the CAMK Ser/Thr protein kinase family, regulates various cellular processes through phosphorylation-independent mechanisms. Dysregulation of TRIB2 has been implicated in promoting tumor growth, metastasis, and therapy resistance, making it a promising target for cancer treatment. In this study, we designed and synthesized a series of TRIB2 PROTAC degraders by conjugating a TRIB2 binder 1 with VHL or CRBN ligands via linkers of varying lengths and compositions.
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