Bilateral vocal cord paralysis in intermediate syndrome: a rare clinical presentation of organophosphorus poisoning.

Organophosphorus poisoning poses a significant health threat, often resulting in high mortality and disability. The intermediate syndrome, characterized by muscle weakness in neck flexors and limbs, is prevalent. While uncommon, cases of vocal cord paralysis have been observed.

Synthesis of Low-Molecular-Weight Fucoidan Analogue and Its Inhibitory Activities against Heparanase and SARS-CoV-2 Infection.

Heparan sulfate (HS) is ubiquitous on cell surfaces and is used as a receptor by many viruses including SARS-CoV-2. However, increased activity of the inflammatory enzyme heparanase (HPSE), which hydrolyses HS, in patients with COVID-19 not only increases the severity of symptoms but also may facilitate the spread of the virus by degrading HS on the cell surface. Therefore, synthetic HPSE blockades, which can bind to SARS-CoV-2 spike protein (SARS-CoV-2-S) and inhibit viral entry, have attracted much attention.

Natural Prenylflavones from the Stem Bark of : Promising Anticancer Agents for Oral Squamous Cell Carcinoma Targeting the Akt/mTOR/STAT-3 Signaling Pathway.

Artonin E (AA2) and artobiloxanthone (AA3) were extracted and purified from the acetone extract of the stem bark of (Parkinson) Fosberg. Preliminary investigations of both candidates revealed promising cytotoxic effects in oral cancer cells. Moreover, these candidates modulated the expression of pivotal proteins linked to oral cancer progression, eliciting apoptosis through caspase-3 and caspase-9 activation.

α/β-Stereo- and diastereoselective glycosylation with -pentenyl glycoside donors, promoted by -iodosuccinimide and catalyzed by chiral Brønsted acid.

A method involving stereoselective glycosylation catalyzed by (+)-isomenthol ester of pentacarbomethoxycyclopentadiene as a chiral Brønsted acid, with -pentenyl glycosides in the presence of -iodosuccinimide as the promoter is described; this method offered a chiral recognition of racemic substrates.

A pentacarbomethoxycyclopentadiene (PCCP) organic Brønsted acid catalyzed stereoselective glycosidation of N-pentenyl orthoesters (NPOE) of d-glucose and d-galactose, in conjunction with N-iodosuccinimide.

Herein, we report our preliminary results in utilizing the organic Brønsted acid, pentacarbomethoxycyclopentadiene (PCCP), for catalysing the glycosidation with n-pentenyl orthoesters (NPOE) of d-glucose and d-galactose in the presence of N-iodosuccinimide (NIS). Benzoyl and benzyl protection in d-glucosyl NPOEs led to 1,2-trans glycosides, while acetyl protection in NPOE led to a mixture of 1,2-cis and trans glycosides with >75% cis selectivity, and d-galactosyl NPOEs led to 1,2-orthoesters. Substrate scope was demonstrated with acceptors of natural product relevance.