East-West Flap After Mohs Micrographic Surgery.

Repair of distal nasal defects resulting from Mohs micrographic surgery is a challenge, but surgeons can choose from a number of techniques. We present 3 cases in which an east-west flap was used to close the defect. The east-west flap is an easily conceived advancement flap that consists of a superior triangle used to cover the defect and an inferior triangle whose base is located along the advancement line.

Adiponectin values are unchanged during pregnancy in rats.

Adiponectin is believed to be a key factor in determining insulin sensitivity. In turn, insulin sensitivity is known to change from an enhanced state in early pregnancy to a reduced one in late pregnancy. A role for adiponectin in these changes has been proposed for mice but questioned for humans.

Resistin expression and plasma concentration peak at different times during pregnancy in rats.

Resistin has been proposed as both an anti-adipogenic factor and an inducer of insulin resistance. During late pregnancy, white adipose tissue mass increases and insulin sensitivity decreases. To check for the involvement of resistin in these processes, we measured plasma resistin in pregnant and non-pregnant rats and in lactating dams.

Leptin release is decreased in white adipocytes isolated from progesterone-treated rats.

Previously, it has been proposed that progesterone has an inhibitory effect on leptin secretion by white adipocytes, because female rats treated with progesterone show unchanged plasma leptin concentrations despite heavier fat depots. In this study, we show that adipocytes isolated from intact rats release the same amount of leptin either in the presence or the absence of progesterone in the incubation medium. However, when we isolated white adipocytes from progesterone-treated and sham-treated rats and measured their leptin release for 6 hr, we found that adipocytes isolated from rats treated with progesterone for 72 hr showed a lower leptin release than those of sham-treated rats.

Effect of acute cold exposure on the expression of the adiponectin, resistin and leptin genes in rat white and brown adipose tissues.

Leptin, adiponectin, and resistin are key hormones produced by adipose tissue. In the present study, we have examined the effects of acute cold exposure (18 h at 6 degrees C) on the expression of the genes encoding these hormones in both brown and white fat of rats. Acute cold exposure resulted in a significant (p < 0.