Publications by authors named "M P A Hoeks"
Importance: Heyde syndrome is the cooccurrence of aortic stenosis and gastrointestinal bleeding secondary to vascular lesions, including angiodysplasias. Several studies have demonstrated cessation of gastrointestinal bleeding after transcatheter aortic valve implantation (TAVI), but the etiology and effects on vascular lesions are largely unknown.
Objective: To examine the associations of TAVI with gastrointestinal vascular lesions and identify factors associated with recovery among patients with iron deficiency anemia and severe aortic stenosis.
Autoimmune hemolytic anemia (AIHA) is a rare autoantibody-mediated disease. For steroid and/or rituximab-refractory AIHA, there is no consensus on optimal treatment. Daratumumab, a monoclonal antibody targeting CD38, could be beneficial by suppression of CD38+ plasma cells and thus autoantibody secretion.
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- Anemia in patients with myelodysplastic syndromes (MDS) negatively impacts their quality of life, and the study aims to assess if weekly low-dose red blood cell (RBC) transfusions could stabilize hemoglobin levels and improve health-related quality of life (HRQoL) compared to the standard transfusion schedule.
- This n-of-1 pilot study involves two treatment arms where patients receive either their usual transfusion schedule or a personalized weekly transfusion, with the effectiveness measured through feasibility, HRQoL, physical function, and RBC usage.
- The trial is ongoing in multiple countries, highlighting differences in RBC provision practices and aiming to gather insights that will shape a larger study on the potential benefits of personalized transfusion
Aims: Heyde syndrome is the co-occurrence of aortic stenosis, acquired von Willebrand syndrome, and gastrointestinal bleeding. Aortic valve replacement has been demonstrated to resolve all three associated disorders. A systematic review and meta-analysis were performed to obtain best estimates of the effect of aortic valve replacement on acquired von Willebrand syndrome and gastrointestinal bleeding.
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