Introduction: Rare and ultra-rare genetic conditions significantly contribute to infant morbidity and mortality, often presenting with atypical features and genetic heterogeneity that complicate management. Rapid genome sequencing (RGS) offers a timely and cost-effective approach to diagnosis, aiding in early clinical management and reducing unnecessary interventions. This pilot study represents the inaugural use of next-generation sequencing (NGS) as a diagnostic instrument for critically ill neonatal and pediatric ICU patients in a Turkish hospital setting.
View Article and Find Full Text PDFThis study investigated the effects of threaded bolt fasteners on the initial and final stiffness of bolted joints in special steel modular construction. A comprehensive set of 246 specimens, including 4, 7.6, and 12 mm thick plates with 20 and 30 mm diameter bolts and different end spacings, were tested.
View Article and Find Full Text PDFBackground: Although international guidelines generally recommend the back to back use of short-acting β-agonists (SABA) within a short time in the management of acute wheezing in children with asthma, there is still uncertainty in the evidence of short term outcome. Thus, this study aimed to investigate the efficacy of back to back and single use of inhaled SABA by lung function testing.
Methods: This was a prospective, double-blinded, placebo controlled study conducted in children ≥6 years of age with a history of asthma.