Publications by authors named "M Ozasa"

Background: Azithromycin has favorable effects on critical respiratory diseases owing to its antimicrobial and anti-inflammatory properties. During the early stages of the coronavirus disease 2019 (COVID-19) pandemic, azithromycin was frequently administered before specific treatments were developed. However, the efficacy of this treatment has not been verified.

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Article Synopsis
  • Cryobiopsy is expected to be increasingly used for diagnosing lung diseases, but traditional methods pose challenges during tracheal intubation with endotracheal tubes.
  • A new method was developed, using a softer endotracheal tube with an externally attached suction tube for safer and simpler Fogarty catheter insertion.
  • The study found that this novel approach resulted in shorter bronchoscopy times without significantly increasing complications, demonstrating its practicality compared to conventional methods.
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Article Synopsis
  • * In a case involving a 78-year-old man, TBLC combined with endobronchial ultrasonography (EBUS) successfully diagnosed adult T-cell lymphoma (ATL), marking it as the first such diagnosis using this method.
  • * A review of literature found 19 total cases of pulmonary lymphomas diagnosed via TBLC, primarily B-cell lymphomas (84.2%), and highlighted the effectiveness and safety of this technique, suggesting more research is needed to refine diagnostic guidelines.
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A 63-year-old Japanese woman with multiple cysts in both lungs on chest computed tomography (CT) was referred to our hospital after a thorough examination, including a transbronchial lung biopsy (TBLB), failed to provide a diagnosis. Based on the findings on chest CT and pathological examination of the bronchoalveolar lavage fluid and transbronchial lung cryobiopsy (TBLC) specimen, the patient was diagnosed with pulmonary Langerhans cell histiocytosis (PLCH). TBLC may replace TBLB as the main diagnostic technique for PLCH, although further studies are required to determine the usefulness of TBLC for the diagnosis of PLCH.

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Sarcoidosis is a systemic inflammatory disease characterized by noncaseating epithelioid cell granulomas. However, certain infections can exhibit similar histological findings. We present a case of a 69-year-old man who was initially diagnosed with sarcoidosis and later was confirmed, through 16S rRNA sequencing, to have disseminated infection.

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