Molecular characterization of methicillin-susceptible/resistant Staphylococcus aureus from bloodstream infections in northern Japan: The dominance of CC1-MRSA-IV, the emergence of human-associated ST398 and livestock-associated CC20 and CC97 MSSA.

Objectives: Staphylococcus aureus (S. aureus) is a major cause of bloodstream infections. The recent epidemiological features and antimicrobial resistance trend were analysed for methicillin-resistant and susceptible S.

RAMP1 Signaling Mitigates Acute Lung Injury by Distinctively Regulating Alveolar and Monocyte-Derived Macrophages.

Acute respiratory distress syndrome (ARDS) is a life-threatening lung injury that induces cytokine hypersecretion. Receptor activity-modifying protein (RAMP) 1, a subunit of the calcitonin gene-related peptide (CGRP) receptor, regulates the production of cytokines. This study examined the role of RAMP1 signaling during lipopolysaccharide (LPS)-induced acute lung injury (ALI).

Ferroelectricity in CsPbNbO and exfoliated 2D nanosheets.

Pb-based perovskites play pivotal roles in ferroelectric research. In the search for new Pb-based ferroelectrics, we investigated the ferroelectric properties of Dion-Jacobson type CsPbNbO and exfoliated 2D nanosheets. Ferroelectricity in CsPbNbO was demonstrated for the first time.

Hetero Cope-Type Hydroamination of Hetero-Allenes with Oximes Having Olefin Moieties Leading to Nitrones, Causing Intramolecular Cycloaddition.

Hetero-allenes such as isocyanates, isothiocyanates, and carbodiimides reacted with oxime having olefin moieties in the manner of hetero Cope-type hydroamination to generate -modified nitrones, which underwent intramolecular cycloaddition to give intramolecular cycloadducts. Among them, the reaction of isocyanates with oximes proceeded at room temperature to provide the corresponding cycloadducts in very high yields. The efficiencies of these sequential cycloadditions were directly compared by competitive reactions.