Publications by authors named "M Orio"
Correction for 'Bio-inspired copper complexes with CuS cores: (solvent) effects on oxygen reduction reactions' by Jordan Mangue , , 2024, , 15576-15582, https://doi.org/10.1039/D4DT01629G.
View Article and Find Full Text PDFThe need for effective alternative energy sources and "green" industrial processes is a more crucial societal topic than ever. In this context, mastering oxygen reduction reactions (ORRs) is a key step to develop fuel cells or to propose alternatives to energy-intensive setups such as the anthraquinone process for hydrogen peroxide production. Achieving this goal using bio-inspired metal complexes based on abundant and non-toxic elements could provide an environmentally friendly option.
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- A study in Chile analyzed antibiotic effectiveness in septic patients suffering from ureterolithiasis-associated urosepsis, highlighting the need for better treatment options to reduce illness and death rates.
- The research involved 52 patients, mostly females with an average age of 52, and found that the majority had Escherichia Coli infections, while all gram-negative bacteria were susceptible to amikacin.
- The study recommends amikacin as the first-choice empirical treatment for this condition, while also advising caution due to its potential kidney toxicity and suggesting a combination of other antibiotics for high-risk patients.
Antibiotic-resistant Enterobacterales pose a major threat to healthcare systems worldwide, necessitating the development of novel strategies to fight such hard-to-kill bacteria. One potential approach is to develop molecules that force bacteria to hyper-activate prodrug antibiotics, thus rendering them more effective. In the present work, we aimed to obtain proof-of-concept data to support that small molecules targeting transcriptional regulators can potentiate the antibiotic activity of the prodrug metronidazole (MTZ) against Escherichia coli under aerobic conditions.
View Article and Find Full Text PDFIn this paper, we employed a multidisciplinary approach, combining experimental techniques and density functional theory (DFT) calculations to elucidate key features of the copper coordination environment of the bacterial lytic polysaccharide monooxygenase (LPMO) from (AA10). The structure of the -enzyme was successfully obtained by X-ray crystallography. We then determined the copper(II) binding affinity using competing ligands and observed that the affinity of the histidine brace ligands for copper is significantly higher than previously described.
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