Publications by authors named "M Onofriescu"
Article Synopsis
- - Lupus nephritis (LN), a common complication of systemic lupus erythematosus (SLE), involves analyzing the distribution of CD4+ and CD8+ lymphocytes in renal biopsies from 53 LN patients to assess their correlation with the severity of kidney lesions.
- - The study used immunohistochemistry to count T lymphocytes in three areas (intraglomerular, periglomerular, and interstitial) and implemented a scoring system to evaluate the severity of kidney damage.
- - Results indicated that CD8+ T lymphocytes outnumbered CD4+ T lymphocytes in every area and LN class, showing a significant correlation with lesion severity, while CD4+ lymphocytes showed no significant
Human immunodeficiency virus (HIV) infection cannot be completely eliminated from the body because the virus integrates its genetic code into that of the host cell. The prevalence of pregnancy in women with HIV infection has increased due to the efficacy of antiretroviral therapy (ART). Placental insufficiency is associated with a reduction in blood flow and circulatory redistribution, resulting in fetal hypoxia and nutrient deprivation as a consequence of an altered placental function, and it can result in a lower birthweight.
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- * A study involving 57 patients from 2017 to 2019 analyzed the characteristics of fibroids during pregnancy, delivery methods, and maternal and fetal outcomes, noting that most women delivered via cesarean section and that fibroids often grow larger in the second trimester.
- * The findings suggest that while myomectomy during cesarean section carries risks like increased operating time, it may be beneficial in selected cases to avoid future surgeries, though significant differences in bleeding between those who had the procedure and those who did not were not observed
Background: The coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produced a pandemic since March 2020 by affecting more than 243 million people with more than 5 million deaths globally. SARS-CoV-2 infection is produced by binding to angiotensin-converting enzyme, which among other sites is highly expressed in the endothelial cells of the blood vessels, pericytes and the heart, as well as in renal podocytes and proximal tubular epithelial cells. SARS-CoV-2 and cardiovascular disease (CVD) are interconnected by risk factors association with an increased incidence of the disease and by determining de novo cardiac complications.
View Article and Find Full Text PDFBackground: Risk assessment tools for predicting mortality and end-stage renal disease (ESRD) in the elderly with CKD have received growing attention. However, integrating risk equations into a multidimensional approach of elderly with CKD stage 3b-4 is lacking.
Methods: In this prospective observational study, we enrolled CKD stage 3b-4 patients aged ≥ 65 years.