Molecular Characterization, Oxidative Stress-Mediated Genotoxicity, and Hemato-Biochemical Changes in Domestic Water Buffaloes Naturally Infected with Under Field Conditions.

(1) Background: Surra is a debilitating disease of wild and domestic animals caused by (), resulting in significant mortality and production losses in the affected animals. This study is the first to assess the genetic relationships of in naturally affected buffaloes from Multan district, Pakistan, using ITS-1 primers and evaluating the effects of parasitemia and oxidative stress on DNA damage and hematobiochemical changes in infected buffaloes. (2) Methods: Blood samples were collected from 167 buffaloes using a multi-stage cluster sampling strategy, and trypomastigote identification was performed through microscopy and PCR targeting RoTat 1.

Water, Sanitation and Hygiene in a Conflict Area: A Cross-Sectional Study in South Kordofan, Sudan.

Background: The UN General Assembly recognised the human right to water and sanitation through the sixth SDG in 2010. South Kordofan, a state in southern Sudan, faces WASH challenges due to conflict, geographical factors, and inadequate services, impacting over 600,000 residents. Such conflicts are well known for spreading diseases and disrupting WASH-related practices among displaced individuals.

Efficacy of Antibiotic Therapy Alone Versus Antibiotics With Percutaneous Drainage in Periappendiceal Abscess: A Systematic Review and Meta-Analysis.

Acute appendicitis is one of the most common surgical emergencies. Simple appendicitis can be a complicated periappendiceal abscess. Despite the fact that there are several treatment options for periappendiceal abscesses, there is no consensus on the optimal treatment method; some surgeons prefer appendectomy, while others prefer relying on non-operative approaches using antibiotic therapy with or without percutaneous drainage.

Purulent Pericarditis and Mycotic Pseudoaneurysm of the Ascending Aorta: A Case Report.

Concomitant presentation of purulent pericarditis and mycotic pseudoaneurysm of the ascending aorta is exceedingly uncommon. We present a case of a 63-year-old male who presented to the emergency department after one week of severe neck pain along with pleuritic chest pain. He was found to have purulent pericarditis associated with a 0.

Novel Uveal Melanoma Patient-Derived Organoid Models Recapitulate Human Disease to Support Translational Research.

Purpose: A lack of representative human disease models has limited the translation of new and more effective treatments in uveal melanoma (UM), the most common primary adult intraocular malignancy. To fill this critical need, we developed and characterized a multicenter biobank of UM patient-derived organoids (PDOs).

Methods: UM patients requiring enucleation from 2019 to 2024 donated tumor tissue for PDO generation.