Publications by authors named "M Olsson"
Telomeres are DNA-protein structures that primarily protect chromosomes and serve multiple functions of gene regulation. When cells divide, telomeres shorten and their main repair system in ectotherms - telomerase - replaces lost nucleotide complexes ((T2AG3)n in vertebrates). It remains a challenge to experimentally investigate resource requirements for telomere maintenance and its effects on lifespan-reproductive tradeoffs in the wild.
View Article and Find Full Text PDFBackground: Gamma Knife radiosurgery (GKRS) is a well-established treatment for residual or growing pituitary adenomas (PAs) post-partial resection. However, some PAs grow even after initial GKRS, for which the efficacy of repeat GKRS is unclear. The primary objective of this study was to determine long-term progression-free survival (PFS) following repeated GKRS in patients with PA.
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- Pituitary adenomas often lead to the need for Gamma Knife radiosurgery (GKRS) after incomplete removal or recurrence, and this study aims to assess its long-term effectiveness.
- In a cohort study of 147 patients who underwent GKRS between 1999 and 2020, the researchers evaluated progression-free survival (PFS) over an average follow-up of 8.1 years, finding a 5-year PFS of 86% and a 10-year PFS of 68%.
- Results indicated that somatotrophic adenomas had lower progression risks, but 32% of patients experienced adverse radiation events, mainly hypopituitarism, highlighting the need to weigh outcomes against potential side effects.
Article Synopsis
- * It found that stronger beliefs in equal childcare (both in what is considered normal and what should be the case) are associated with the availability of parental leave policies.
- * While the data suggests that changes in parental leave policies can shift perceptions of social norms over time, the study acknowledges that it cannot definitively determine cause-and-effect relationships due to its cross-sectional design.
Objective: The aim of this study is to evaluate treatment patterns and long-term oncological outcomes of patients with locally advanced prostate cancer (LAPCa).
Patients And Methods: This is a population-based study including LAPC (cT3-4, M0) patients from the Stockholm region (Sweden). A sub-analysis was performed in men treated with primary cystoprostatectomy or total pelvic exenteration (TPE) for cT4 prostate cancer (PCa).