Publications by authors named "M Olley"
Article Synopsis
- * The enzyme CHAC1 facilitates the breakdown of glutathione to help maintain the mitochondrial cysteine pool, crucial for Fe-S protein function during nutrient scarcity.
- * Disrupting the synthesis of Fe-S clusters under conditions of limited cysteine appears to protect cells from ferroptosis, indicating mitochondrial metabolism plays a key role in cellular survival when nutrients are low.
Background And Aims: Multiple interventions and policy changes related to opioid agonist treatment (OAT) have been introduced in British Columbia, Canada to increase engagement and retention in OAT. We aimed to estimate the impact of policy changes and the announcement of the opioid overdose-related public health emergency on the use of OAT for incarcerated individuals with opioid use disorder.
Design: Interrupted time-series analysis.
The increasing emergence of multidrug-resistant infection causing microorganisms has become a significant burden globally. Despite the efforts of pharmaceuticals in producing relatively new antimicrobial drugs, they have resulted in a high rate of mortality, disability and diseases across the world especially in developing countries. Supporting this claim was the report of the Centre for Disease Control and Prevention (CDC) who estimated that over 2 million illnesses and 23,000 deaths per year are attributable to antibiotic resistant pathogens in the United States.
View Article and Find Full Text PDFBackground: Enterobacteriaceae are ubiquitously present in nature and can be found in the intestinal tract of humans and animals as commensal flora. Multidrug-resistant Enterobacteriaceae are increasingly reported and are a threat to public health implicating a need for accurate identification of the isolates to species level. In developing countries, identification of bacteria basically depends on conventional methods: culture and phenotypic methods that hamper the accurate identification of bacteria.
View Article and Find Full Text PDFBackground: Wound infections are associated with increased morbidity and mortality.
Objectives: To determine the prevalence, aetiology and susceptibility profile of bacterial agents of wound infection among in- and- out patients at a rural tertiary hospital in Nigeria, within a 5 year period.
Methods: Wound swabs collected from 156 out-patients and 353 in-patients were, cultured and microbial isolates identified using standard methods.