Publications by authors named "M Olive Plana"
Objectives: Anti-PD-(L)1 agents changed the landscape of recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) treatment. Previous studies showed improved response rates to salvage chemotherapy (SCT) after progression to anti-PD-(L)1 agents. This study aims to evaluate the outcomes of SCT and to identify predictors of response and survival in patients with R/M HNSCC.
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- Allergic rhinitis is a common health problem, affecting many people and getting worse because of climate change and pollution.
- Allergen immunotherapy (AIT) is a special treatment that can help people with allergies, and it's shown to be effective and cost-effective compared to standard treatments.
- Recent studies found that AIT treatments like subcutaneous and sublingual immunotherapy are not just effective but also save money in the long run, especially when combined with other treatments for allergies and asthma.
Article Synopsis
- Laryngeal preservation strategies in LA-LHSCC focus on curing the disease while keeping the larynx functional, reducing the need for total laryngectomy and its negative effects on quality of life.* -
- Various non-surgical treatments like radiotherapy and chemoradiation have been explored, but reliable predictors for treatment success are still lacking, which poses a significant clinical challenge.* -
- The PRESERVE trial aims to address this issue by analyzing past data to create a predictive classifier that combines various patient data types, ultimately improving patient selection for laryngeal preservation treatments.*
Objective: This study aimed to identify biochemical, hematological, and endocrinological abnormalities in a sample of children and adolescents with underweight AN and atypical AN and to compare these results between the two groups.
Method: Based on the 5th BMI-percentile admission, adolescents with underweight AN (n = 520) and atypical AN (n = 255) were included and medical records were reviewed.
Results: Low prealbumin (35%) and neutropenia (39%), and several abnormalities in endocrinological parameters (50%) were the most common alterations found in the whole sample.
Article Synopsis
- Current SARS-CoV-2 mRNA vaccines are effective, but there's a need for new strategies due to waning immunity and variant emergence, prompting this study on a heterologous mRNA/MVA vaccination approach.
- The research demonstrates that a combination of a trimeric receptor binding domain (RBD) delivered via mRNA and a modified vaccinia virus (MVA) boost creates strong immune responses, including effective antibodies and T cell activity against various SARS-CoV-2 strains.
- The heterologous regimen provided complete protection in specific mouse models after exposure to the virus, outperforming traditional methods and suggesting that alternative nanocarrier technologies could enhance vaccine effectiveness while avoiding patent issues.