* The study focused on the inflammation-related cytokine IL-31 and its receptor IL-31RA, finding higher levels of these in PH and pemphigus vegetans (PVe), indicating a potential link to pruritus in PH.
* While there were increases in certain immune cells (eosinophils and basophils) in PH and PVe, the overall mechanisms driving itching seem distinct, with IL-31 signaling not triggering itch in the