BCCHI-HCNN: Breast Cancer Classification from Histopathological Images Using Hybrid Deep CNN Models.

Breast cancer is the most common cancer in women globally, imposing a significant burden on global public health due to high death rates. Data from the World Health Organization show an alarming annual incidence of nearly 2.3 million new cases, drawing the attention of patients, healthcare professionals, and governments alike.

Polyphasic approaches to identify and understand α-glucosidase inhibitory potential of secondary metabolites of Withania coagulans fruit.

Withania coagulans (WC) is used in traditional and Ayurveda medicine to treat various ailments, including diabetes. Our investigation found that WC fruit hexane extract effectively suppresses α-glucosidase activity (IC = 0.013 mg/ml, K = 0.

Light-Activated Molecular Purification (LAMP) of Recombinant Proteins.

The production of recombinant proteins has become a focal point in biotechnology, with potential applications in catalysis, therapeutics, and diagnostics. Before their application, these proteins undergo cumbersome downstream processing, including multiple resin-based chromatography steps (ion exchange or affinity-based) to isolate the protein of interest from host cell proteins, which are more abundant. These methods often involve (1) nonspecific binding of host cell proteins onto the resin, (2) a trial and error approach in determining elution conditions for the protein of interest, and (3) complex functionalization of the resin.