Comparative evaluation of renoscintigraphic properties and plasma clearance of 99MTc-DADS (99mTc-N,N'-bis/mercaptoacetamido ethylenediamine), 99mTc-DTPA and 131I-o-hippuran.

Plasma clearance of 99mTc-N,N'-bis (1,2-mercaptoacetamido) ethylenediamine (DADS), 99mTc-DTPA and 131I-o-hippuran (OIH) was determined in rabbits from blood-concentration decay curves after single i.v. injection of the compounds.

An attempt to use the Tc-99m-thiodisuccinic acid (TDSA) complex in renoscintigraphy. II. In vivo studies.

In the study the usefulness of Tc-99m-TDSA complex for renoscintigraphy was investigated. The results suggest that the complex undergoes elimination primarily via glomerular filtration similarly to Cr-51-EDTA and Tc-99-DTPA. Respective renoscintigraphic curves were obtained.

An attempt to use the Tc-99m-thiodisuccinic acid (TDSA) complex in renoscintigraphy. I. Preparation of the complex.

Attempts to apply thiodisuccinic acid for assessment of kidney function prompted a study on optimal conditions of labelling the compound with Tc-99m. The optimal pH, incubation time, temperature at labelling and amounts of necessary reagents were determined which permit to obtain Tc-99m-TDSA complex of 97% purity. An appropriate Kit was developed for ex promptu preparation of the complex.

99mTc-unithiol complex, a new radiopharmaceutical for kidney scintigraphy. IV. Autoradiographic localisation of its cellular distribution in the kidney.

The distribution of 99mTc-Unithiol complex was studied by macro-autoradiography in rats and in rabbit kidneys, and the presence of activity in the renal cortex was easily demonstrated. Using micro-autoradiography, the accumulation of activity in various parts of the nephron was observed to concentrate in the cells of the proximal and distal tubuli to a larger extent than in the glomeruli.