Publications by authors named "M Oggioni"
Efficient utilization of nutrients is crucial for microbial survival and virulence. The same nutrient may be utilized by multiple catabolic pathways, indicating that the physical and chemical environments for induction as well as their functional roles may differ. Here, we study the tagatose and Leloir pathways for galactose catabolism of the human pathogen Streptococcus pneumoniae.
View Article and Find Full Text PDFEvaluation of the apportionment of genetic diversity of human bacterial commensals within and between human populations is an important step in the characterization of their evolutionary potential. Recent studies showed a correlation between the genomic diversity of human commensal strains and that of their host, but the strength of this correlation and of the geographic structure among human populations is a matter of debate. Here, we studied the genomic diversity and evolution of the phylogenetically related oro-nasopharyngeal healthy-carriage Streptococcus mitis and Streptococcus pneumoniae, whose lifestyles range from stricter commensalism to high pathogenic potential.
View Article and Find Full Text PDFArticle Synopsis
- Enterovirus D68 (EV-D68) infections can cause severe respiratory issues and acute flaccid myelitis, with a significant rise reported during the fall-winter season of 2021-2022 across Europe.
- The study by the European Non-Polio Enterovirus Network (ENPEN) analyzed over 10,481 samples from 19 countries, identifying 1,004 as EV-D68, predominantly affecting young children, where 37.9% required hospitalization.
- Additionally, genetic analyses uncovered two new B3-derived lineages without regional patterns, indicating a notable impact of the infections and the emergence of new virus strains.
Background: People with cystic fibrosis (pwCF) are considered at risk of developing severe forms of respiratory viral infections. We studied the consequences of COVID-19 and virus-host cell interactions in CF vs. non-CF individuals.
View Article and Find Full Text PDFIncreased circulation of echovirus 11 in the general population and hospital patients as elicited by the non-polio enterovirus laboratory-based sentinel surveillance in northern Italy, 2023.
Int J Infect Dis
May 2024
Article Synopsis
- Following reports of echovirus 11 (E-11) infections in neonates in Europe, an investigation took place in northern Italy from August 2021 to June 2023 to monitor E-11 circulation through community and hospital surveillance of enteroviruses.
- The investigation utilized virological data from both outpatient cases of influenza-like illness and hospitalized patients with respiratory or neurological symptoms, analyzing the VP1 gene for molecular characterization.
- Results showed an increase of E-11 cases in early 2023, particularly severe cases among neonates, with the majority linked to a novel E-11 variant first identified in France, indicating a concerning trend in E-11 transmission.