Publications by authors named "M Oest"

Apples are among the most important fruits worldwide and the most consumed fruit in Germany. Due to higher energy and personnel costs, domestic apples are more expensive and thus offer an incentive for mixing with foreign goods. Moreover, imported apples have a higher carbon footprint, which is an obstacle regarding sales in times of climate change.

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  • Radiotherapy (RTx) is a cancer treatment that can make bones weaker and more prone to fractures after treatment.
  • In a study, rat femurs (thigh bones) were irradiated to see how RTx affects their strength and any damage caused by stress.
  • The results showed that RTx significantly weakened the bones and caused more damage over time, even though the overall bone shape and density stayed the same.
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Both high-cycle fatigue life and fatigue crack propagation resistance of human cortical bone allograft are radiation dose-dependent between 0 and 25 kGy such that higher doses exhibit progressively shorter lifetimes. Recently, we have shown that collagen chain fragmentation and stable crosslink accumulation may contribute to the radiation dose-dependent loss in fatigue crack propagation resistance of human cortical bone. To our knowledge, the influence of these mechanisms on high-cycle fatigue life of cortical bone have not been established.

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Bone fragility is a well-documented long-term side effect of radiotherapy, which currently has no preventative treatments. In this study, we applied a caloric restriction (CR) diet to attenuate both local and systemic bone loss after irradiation (RTx) in an established female Balb/c mouse model (4 consecutive daily doses of 5 Gy to the right hindlimb only). CR mice were tapered down to a 30% reduced calorie diet (RTx/CR) one week before irradiation, while regular diet (RD) mice received food ad libitum (RTx/RD).

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  • The wrapping technique aims to protect nerves from scar tissue and enhance their function, particularly after neurolysis for conditions like cubital tunnel syndrome (CuTS).
  • A study analyzed the effectiveness of AxoGuard® nerve protector, a porcine-derived matrix used during revision surgeries for CuTS, comparing outcomes between patients who had only surgery versus those who received the nerve wrapping.
  • Results showed that the wrapping group had significantly better clinical improvement, with 84.4% achieving excellent or good outcomes and no complications related to the implant, indicating that PECM wrapping may help reduce nerve scarring and improve nerve function.
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