Neurological Pupil Index and Intracranial Hypertension in Patients With Acute Brain Injury: A Secondary Analysis of the ORANGE Study.

Importance: Invasive intracranial pressure (ICP) is the standard of care in patients with acute brain injury (ABI) with impaired consciousness. The Neurological Pupil Index (NPi) obtained by automated pupillometry is promising for noninvasively estimating ICP.

Objectives: To evaluate the association between repeated NPi and invasive ICP values.

Integrating Plastic Waste into Concrete: Sustainable Solutions for the Environment.

Plastic waste management has received significant attention in recent decades due to the urgent global environmental crisis caused by plastic pollution. The versatile and durable nature of plastic has led to its widespread usage across various sectors. However, its nonbiodegradable nature contributes to unsustainable production practices, leading to extensive landfill usage and posing threats to marine ecosystems and the food chain.

Ketone Bodies after Cardiac Arrest: A Narrative Review and the Rationale for Use.

Cardiac arrest survivors suffer the repercussions of anoxic brain injury, a critical factor influencing long-term prognosis. This injury is characterised by profound and enduring metabolic impairment. Ketone bodies, an alternative energetic resource in physiological states such as exercise, fasting, and extended starvation, are avidly taken up and used by the brain.

Early sedation in traumatic brain injury: a multicentre international observational study.

We aimed to investigate the use of sedation in patients with severe traumatic brain injury (TBI), focusing on the choice of sedative agent, dose, duration, and their association with clinical outcomes. Multinational, multicentre, retrospective observational study. 14 trauma centres in Europe, Australia and the United Kingdom.