Diagnosis of Leptomeningeal Disease in Diffuse Midline Gliomas by Detection of H3F3A K27M Mutation in Circulating Tumor DNA of Cerebrospinal Fluid.

Introduction: Leptomeningeal disease (LMD) in diffuse midline gliomas (DMGs) can lead to devastating symptoms such as severe pain, urinary incontinence, and tetraparesis, with limited treatment options. We determined whether detecting H3F3A K27M-mutant droplets in cerebrospinal fluid (CSF) circulating tumor deoxyribonucleic acid (ctDNA) could be a biomarker for detecting LMD in DMGs.

Methods: Twenty-five CSF samples were obtained from 22 DMG patients.

Successful use of gadolinium contrast medium for flow-diverter stent placement in a patient with hypersensitivity to iodinated contrast: A case report.

Gadolinium contrast medium can serve as an alternative to iodinated contrast medium when the latter is unsuitable. In this report, we describe a case of a carotid-ophthalmic aneurysm in which angiograms were obtained using gadolinium contrast medium for flow-diverter stent placement due to the patient's history of bronchial asthma and hypersensitivity reactions to iodinated contrast medium. To enhance the visibility of gadolinium contrast medium, which typically provides lower contrast compared to iodinated contrast medium, we employed a contrast-enhancing and noise-reducing protocol on our image-guided therapy system.

Investigation of functional connectivity differences based on anxiety tendencies.

Introduction: Anxiety is an emotion necessary for human survival. However, persistent and excessive anxiety can be clinically challenging. Increased anxiety affects daily life and requires early detection and intervention.

2D-to-1D Conversion of a Layered Sodium Titanate via Rational Framework Splitting for Highly Efficient Cation Exchange.

Demand on high-performance ion exchangers is ever-increasing in energy and environment applications. Among many cation exchangers, layered alkali titanates generally show larger cation exchange capacity, but slower cation exchange rate due to their 2D micrometer-size particle morphologies, which limits their practical applications. Here, a rational conversion of a layered sodium titanate, NaTiO, is reported to the corresponding 1D ultra-narrow nanowires via hydrothermal treatment under basic conditions.