mir-276a Is Required for Muscle Development in and Regulates the FGF Receptor During the Migration of Nascent Myotubes in the Testis.

MicroRNAs function as post-transcriptional regulators in gene expression and control a broad range of biological processes in metazoans. The formation of multinucleated muscles is essential for locomotion, growth, and muscle repair. microRNAs have also emerged as important regulators for muscle development and function.

Stepwise microsolvation of HCl revisited: Infrared investigation of selectively deuterated (HCl)m(H2O)n (m + n ≤ 4) cluster molecules.

In a recent theoretical investigation of DCl-H2O, HCl-D2O, and DCl-D2O [Felker et al., J. Phys.

Dipeptidic Phosphonates: Potent Inhibitors of Pseudomonas aeruginosa Elastase B Showing Efficacy in a Murine Keratitis Model.

The ubiquitous opportunistic pathogen Pseudomonas aeruginosa is responsible for severe infections and notoriously known for acquiring antimicrobial resistance. Inhibiting the bacterium's extracellular elastase, LasB - a zinc-dependent protease - presents a promising strategy to mitigate its virulence. Within this medicinal chemistry-driven hit-to-lead optimization campaign, a new series of highly potent dipeptidic phosphonates is designed and synthesized following a structure-based drug-discovery approach.

[New innovations in cross-sectional imaging diagnostics of the aorta].

Imaging, particularly computed tomography (CT) and magnetic resonance imaging (MRI), plays a central role in the diagnostics, treatment planning and follow-up of aortic diseases. While ultrasound is often used for the initial assessment, CT enables rapid and comprehensive imaging of the aorta. The MRI is a radiation-free and when necessary, contrast agent-free alternative and provides functional imaging methods.

Tracheal tuft cells release ATP and link innate to adaptive immunity in pneumonia.

Tracheal tuft cells shape immune responses in the airways. While some of these effects have been attributed to differential release of either acetylcholine, leukotriene C4 and/or interleukin-25 depending on the activating stimuli, tuft cell-dependent mechanisms underlying the recruitment and activation of immune cells are incompletely understood. Here we show that Pseudomonas aeruginosa infection activates mouse tuft cells, which release ATP via pannexin 1 channels.