Curcumin Modulates Platelet Activation and ROS Production Induced by Amyloid Peptides: New Perspectives in Attenuating Prothrombotic Risk in Alzheimer's Disease Patients.

Background/objectives: Amyloid peptides, whose accumulation in the brain as senile plaques is associated with the onset of Alzheimer's disease, are also found in cerebral vessels and in circulation. In the bloodstream, amyloid peptides promote platelet adhesion, activation, oxidative stress, and thrombosis, contributing to the cardiovascular complications observed in Alzheimer's disease patients. Natural compounds, such as curcumin, are known to modulate platelet activation induced by the hemostatic stimuli thrombin and convulxin.

On-beat rhythm and working memory are associated with better speech-in-noise perception for older adults with hearing loss.

Even with the use of hearing aids (HAs), speech in noise perception remains challenging for older adults, impacting communication and quality of life outcomes. The association between music perception and speech-in-noise (SIN) outcomes is of interest, as there is evidence that professionally trained musicians are adept listeners in noisy environments. Thus, this study explored the association between music processing, cognitive factors, and the outcome variable of SIN perception, in older adults with hearing loss.

Enhancement of chemotherapy effects by non-lethal magneto-mechanical actuation of gold-coated magnetic nanoparticles.

Remote magneto-mechanical actuation (MMA) of magnetic nanoparticles (MNP) is emerging as a promising therapy method in oncology. However, translation to the clinic faces the challenge of whole-body action and the reluctance about indiscriminate mechanical action of the nanoparticles on tumor and healthy cells. Here, we show how the MMA method based on magnetically-rotated gold-coated MNP boosts only the activity of an unbound antitumor drug, without physical damage of cells via MNP.

OMI-based emission source classification in East China and its spatial redistribution in view of pollution control measures.

This study aims to generate a satellite-based qualitative emission source characterization for the heavily polluted eastern part of China in the 2010-2016 time period. The applied source identification technique relies on satellite-based NO and SO emission estimates by OMI, their SO:NO ratio, and the MIX anthropogenic emission inventory to distinguish emissions from different emission categories (urban, industrial, natural) and characterize the dominant source per 0.25° × 0.