Publications by authors named "M O Samuel"
A major concern of xenotransplantation is that donor organs may be a source of pathogens. One pathogen in particular, porcine cytomegalovirus (PCMV), a porcine roseolovirus (PRV), is thought to result in donor organ failure in an immunosuppressed state. Porcine cytomegalovirus is difficult to detect in organ donor swine because of its ability to establish latency.
View Article and Find Full Text PDFIntroduction: This systematic review and meta-analysis aimed to evaluate the effectiveness and safety of adjunct systemic corticosteroid therapy in patients admitted to the intensive care unit (ICU) with bacterial community-acquired pneumonia (CAP).
Method: We searched MEDLINE, Embase and the Cochrane Library to identify randomised controlled trials (RCTs) published from the databases' inception to February 2024. All RCTs evaluating the effect of systemic corticosteroids on mortality, compared to standard of care among adult bacterial CAP patients admitted to ICU were included.
Unlabelled: This systematic review of 18 RCTs assessed the impact of yoga on balance, fall risk, fear of falling, bone mineral density (BMD), and bone turnover markers in healthy individuals. Yoga significantly improved balance but its effects on BMD were inconclusive. Standardised protocols and longer-term studies are needed.
View Article and Find Full Text PDFArticle Synopsis
- The study examines the long-term outcomes of patients with univentricular heart and total cavopulmonary connection Fontan, focusing on those with hypoplastic left heart syndrome (HLHS) compared to other types.
- The research found that patients with HLHS experienced a significantly higher incidence of adverse cardiovascular events, including death and transplantation, with a hazard ratio indicating over six times the risk.
- The findings suggest that HLHS is a critical factor in determining poorer outcomes in patients with this heart condition.
Article Synopsis
- * The study identified that certain genetic predispositions, specifically related to insulin deficiency and fat distribution, are strongly linked to earlier T2D diagnosis, averaging 8.2 years sooner for those at high genetic risk.
- * Individuals with these genetic risk factors also faced faster progression to serious complications, like needing insulin treatment and other health issues, and they showed poorer responses to diabetes medication compared to those with lower genetic risks.