Access to Heterobimetallic M/Cu Complexes with a Multichelate Platform and Their Reactivity Studies in CO2RR.

We describe the selective formation of heterobimetallic complexes, exploiting the coordination trends of the developed bis-terpyridyl -1,2-cyclohexadiamine platform (). Following a stepwise addition, we first reacted ligand toward tetrakisacetonitrile transition metal precursors, [M(MeCN)][BF] (where M = Fe or Ni), to generate the monometallic complexes ([FeL][BF]) and ([NiL][BF]). These species were later combined with the tetrakisacetonitrile precursor [Cu(MeCN)][BF], generating the corresponding heterobimetallic complexes ([FeCuL(MeCN)][BF]) and ([NiCuL(MeCN)][BF]).

How will the cumulative effects of fishing and climate change affect the health and resilience of the Celtic Sea ecosystem?

Ecosystems are subject to increasing anthropogenic pressures worldwide. Assessing cumulative effects of multiple pressures and their impacts on recovery processes is a daunting scientific and technical challenge due to systems' complexity. However, this is of paramount importance in the context of ecosystem-based management of natural systems.

Tear Protein Biomarkers for Ocular Mucous Membrane Pemphigoid Uncovered Using Targeted LC-MS/MS.

Mucous membrane pemphigoid (MMP) is a multisystemic rare autoimmune disease affecting the skin and mucous membranes. Ocular involvement is characterized by chronic conjunctival inflammation causing scar formation, leading to corneal opacification and vision loss. Conjunctival biopsies are currently used to confirm diagnosis, and the associated immunosuppression treatments prescribed can have serious consequences on patients.

[Artificial intelligence in healthcare: A survival guide for internists].

Artificial intelligence (AI) is experiencing considerable growth in medicine, driven by the explosion of available biomedical data and the emergence of new algorithmic architectures. Applications are rapidly multiplying, from diagnostic assistance to disease progression prediction, paving the way for more personalized medicine. The recent advent of large language models, such as ChatGPT, has particularly interested the medical community, thanks to their ease of use, but also raised questions about their reliability in medical contexts.

Chiasmal Decussation in Oculo-Cutaneous Albinism Type 8.

Purpose: Albinism is a genetic disorder characterized by a defect in melanin biosynthesis. Ophthalmological and dermatological impairments vary according to the patient genotype and are highly heterogenous. Recently, variants in the DCT gene were showed to be responsible for a new type of oculocutaneous albinism (OCA) named OCA8.