Publications by authors named "M O Revel"
Sickle cell disease (SCD) is the most common genetic disease in the world and a societal challenge. SCD is characterized by multi-organ injury related to intravascular hemolysis. To understand tissue-specific responses to intravascular hemolysis and exposure to heme, we present a transcriptomic atlas in the primary target organs of HbSS vs HbAA transgenic SCD mice.
View Article and Find Full Text PDFThe use of rare earth elements has increased in recent years, leading to a rise in environmental concentrations. Despite the growth in number of studies regarding toxicity, knowledge gaps remain. For Daphnia magna, standardized test methods involve exposure periods of either 48 h or 21 days to assess toxicological effects.
View Article and Find Full Text PDFStreptococcus pneumoniae (SP) remains an important cause of community acquired pneumonia (CAP). We aimed to describe the prevalence and characteristics of outpatients with radiologically confirmed pneumococcal CAP. Between November 2017 and December 2019, a French network of general practitioners enrolled CAP-suspected adults, with ≥1 clinical signs of infection and ≥1 signs of pulmonary localization in an observational study.
View Article and Find Full Text PDFArticle Synopsis
- Gadolinium (Gd) is a lanthanide metal that poses acute toxicity risks due to its use in technology, with toxicity reliant on ion concentrations and chemical speciation.
- The Biotic Ligand Model (BLM) was developed to assess Gd's toxicity to the freshwater crustacean Daphnia magna, validated using various cation concentrations and real water samples from France and Germany.
- Results showed that major cations like potassium, magnesium, and calcium compete with Gd for binding sites, leading to successful toxicity predictions in many freshwater samples, although challenges arose with high conductivity and low pH conditions.
Purpose: For most guidelines, diagnosis of community-acquired pneumonia (CAP) is based on a combination of clinical signs and focal consolidation visible on chest radiographs (CRs). Our objective was to analyze antibiotic initiation by general practitioners for patients with suspected CAP according to CR.
Methods: We conducted a prospective cross-sectional study in general practice in France.