Time-efficient approach for environmental transformation and bioavailability assessment of isotopically enriched nanoparticles to increase environmental relevance.

The increasing use of engineered nanoparticles (NPs) and their release into the environment requires an assessment of their fate and (eco-) toxicological effects. Previous studies have often focused on pristine NPs or NPs spiked into the effluent of simulated wastewater treatment plants (WWTP) fed with artificial wastewater, combined with unrealistic high exposure concentrations to overcome problems associated with high metal background concentrations. In this study environmentally transformed NPs were obtained by direct spiking into an anaerobic digester filled with municipal sewage sludge.

Cross-Coupling Reactions with Nickel, Visible Light, and -Butylamine as a Bifunctional Additive.

Transition metal catalysis is crucial for the synthesis of complex molecules, with ligands and bases playing a pivotal role in optimizing cross-coupling reactions. Despite advancements in ligand design and base selection, achieving effective synergy between these components remains challenging. We present here a general approach to nickel-catalyzed photoredox reactions employing -butylamine as a cost-effective bifunctional additive, acting as the base and ligand.

Bi-allelic KICS2 mutations impair KICSTOR complex-mediated mTORC1 regulation, causing intellectual disability and epilepsy.

Nutrient-dependent mTORC1 regulation upon amino acid deprivation is mediated by the KICSTOR complex, comprising SZT2, KPTN, ITFG2, and KICS2, recruiting GATOR1 to lysosomes. Previously, pathogenic SZT2 and KPTN variants have been associated with autosomal recessive intellectual disability and epileptic encephalopathy. We identified bi-allelic KICS2 variants in eleven affected individuals presenting with intellectual disability and epilepsy.

Long-term recurrence after parathyroidectomy in primary hyperparathyroidism-do predictors exist?

Background: Primary hyperparathyroidism (pHPT) is the third most common endocrine disease, affecting predominantly postmenopausal women. About 85% of cases are caused by a solitary parathyroid adenoma which leads to a hypersecretion of the parathyroid hormone (PTH) and consequently to elevated serum calcium concentrations. Parathyroidectomy is the only curative treatment.

Optimizing post-surgical outcomes: unveiling the importance of patient-reported outcomes with insights from the schulthess local shoulder arthroplasty registry.

Objective: The establishment of clinical registries is essential for the comprehensive evaluation of surgical outcomes. In 2006, the Schulthess Shoulder Arthroplasty Registry (SAR) was launched to systematically assess safety, implant longevity, functional outcomes, pain levels, quality of life, and patient satisfaction in individuals undergoing shoulder arthroplasty. This paper aims to outline the registry data and demonstrate how it is leveraged to improve clinical outcomes.