Publications by authors named "M O Ogunlewe"
Article Synopsis
- The study investigates damaging mutations in the human genome that may contribute to nonsyndromic cleft lip with or without cleft palate (nsCL ± P), focusing on high-impact mutations in African and Brazilian cohorts.* -
- Researchers utilized next-generation sequencing (NGS) and whole-exome sequencing to identify pathogenic variants and discovered several damaging mutations in a gene related to cell adhesion, which has a link to cleft palate in mice.* -
- The findings highlight the significance of the gene encoding AFADIN in the risk for nsCL ± P in humans and emphasize the effectiveness of combining NGS with computational analysis to better understand this condition's genetic basis.*
Presentation and Management of Atypical Orofacial Clefts: A Single-Institution Experience for 13 Year Period.
Cleft Palate Craniofac J
February 2023
This study reviews the craniofacial clefts that presented at a Nigerian tertiary health facility, highlighting our experience with the pattern of presentation and surgical care of these patients. A retrospective review of the smile train database and medical records of all individuals who had been diagnosed with any of the Tessier craniofacial clefts and managed between 1st January 2007 and 31st December 2020 was done. The data were presented as numbers and percentages of cases.
View Article and Find Full Text PDFObjective: Nonsyndromic cleft lip and/or cleft palate (NSCL/P) have multifactorial etiology where genetic factors, gene-environment interactions, stochastic factors, gene-gene interactions, and parent-of-origin effects (POEs) play cardinal roles. POEs arise when the parental origin of alleles differentially impacts the phenotype of the offspring. The aim of this study was to identify POEs that can increase risk for NSCL/P in humans using a genome-wide dataset.
View Article and Find Full Text PDFThis study aimed to determine the normative facial anthropometry measurement among Nigerians using three-dimensional stereophotogrammetry analysis.This study was carried out in Lagos, Nigeria over a period of 3 years. The sample population was Nigerians of diverse ethnic groups, age 16 and above with no history of congenital or acquired craniofacial deformities.
View Article and Find Full Text PDFAim: The aim of the study was to investigate the role of variants in GJB2 gene in the etiology of hearing defects in nonsyndromic cleft lip/palate.
Method: Saliva samples were obtained from cases (subjects with orofacial clefts) and control (subjects without orofacial clefts) who consented to the study. Deoxyribonucleic acid (DNA) was extracted using standardized protocol at Butali Lab (Iowa, IA).