Publications by authors named "M O Mewes"

Background: While inter-hospital transfers for patients who have suffered major trauma have been well investigated, patient flows for other injured patients, or cases with orthopedic complications, are rarely described. This study aims to analyze the affected collective and to show possible reasons, patterns, and pitfalls to optimize the process in future.

Materials And Methods: In a prospective cohort study, all consecutive transfers to a Level I trauma center in Germany were documented and assessed.

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DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase (DP) is a 6   6   6 m liquid argon time-projection-chamber (LArTPC) that recorded cosmic-muon data at the CERN Neutrino Platform in 2019-2020 as a prototype of the DUNE Far Detector. Charged particles propagating through the LArTPC produce ionization and scintillation light.

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The Deep Underground Neutrino Experiment (DUNE) will be a powerful tool for a variety of physics topics. The high-intensity proton beams provide a large neutrino flux, sampled by a near detector system consisting of a combination of capable precision detectors, and by the massive far detector system located deep underground. This configuration sets up DUNE as a machine for discovery, as it enables opportunities not only to perform precision neutrino measurements that may uncover deviations from the present three-flavor mixing paradigm, but also to discover new particles and unveil new interactions and symmetries beyond those predicted in the Standard Model (SM).

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Unlabelled: Severe inborn cardiac malformations are typically corrected in cardioplegia, with a cardio-pulmonary bypass (CPB) taking over body circulation. During the operation the arrested hearts are subjected to a global ischemia/reperfusion injury. Although the applied cardioplegic solutions have a certain protective effect, application of additional substances to reduce cardiac damage are of interest.

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Article Synopsis
  • The vascular endothelium functions as a barrier and relies on Ca signaling for responses to stimuli like ATP, primarily involving Ca release from the endoplasmic reticulum (ER).
  • Research shows that inhibiting the soluble adenylyl cyclase (sAC) significantly reduces ATP-induced Ca elevation in endothelial and smooth muscle cells, unlike transmembrane adenylyl cyclase (tmAC) inhibitors.
  • Findings suggest that sAC plays a crucial role in regulating calcium responses in the vascular endothelium, indicating its potential as a target for treatments in conditions like arterial hypertension and heart failure.
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