Publications by authors named "M O Manis"
Objective: To describe the collection methods for perilymph fluid biopsy during cochlear implantation, detect levels of amyloid β 42 and 40 (Aβ and Aβ), and total tau (tTau) analytes with a high-precision assay, to compare these levels with patient age and Montreal Cognitive Assessment (MoCA) scores, and explore potential mechanisms and relationships with otic pathology.
Study Design: Prospective study.
Setting: Tertiary referral center.
Article Synopsis
- The study aimed to investigate how pharmacists contribute to the postdischarge care of patients suffering from kidney disease.
- It analyzed various interventions from 10 studies, focusing on areas like medication management and patient education, with some showing positive outcomes related to patient care metrics.
- Ultimately, the findings highlight the pharmacist's potential role in multidisciplinary teams but indicate variability in their effectiveness and lack of standardized practices.
Apolipoprotein E (APOE) is a strong genetic risk factor for late-onset Alzheimer's disease (LOAD). APOE4 increases and APOE2 decreases risk relative to APOE3. In the P301S mouse model of tauopathy, ApoE4 increases tau pathology and neurodegeneration when compared with ApoE3 or the absence of ApoE.
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