Publications by authors named "M O Lederer"
The Hippo/YAP1 signaling pathway regulates normal development by controlling contact inhibition of growth. In cancer, YAP1 activation is often dysregulated, leading to excessive tumor growth and metastasis. SRC kinase can cross talk to Hippo signaling by disrupting adherens junctions, repressing the Hippo cascade, or activating YAP1 to promote proliferation.
View Article and Find Full Text PDFIn recent years, optical temperature probes operating in the second near-infrared (BW-II) and third near-infrared (BW-III) biological windows have garnered significant attention in the scientific community. For biological applications these probes offer distinct advantages, including enhanced tissue penetration depth, minimal autofluorescence, and a remarkable improvement in imaging sensitivity and spatial resolution. Moving toward theranostic applications, there is a growing demand for the development of materials that integrate both BW-II and BW-III thermometry systems with drug delivery functionalities.
View Article and Find Full Text PDFThe most efficient upconversion (UC) materials reported to date are based on fluoride hosts with low phonon energies, which reduce the amount of nonradiative transitions. In particular, NaYF doped with Yb and Er at appropriate ratios is known as one of the most efficient UC phosphors. However, its low thermal stability limits its use for certain applications.
View Article and Find Full Text PDFArticle Synopsis
- Deep random forest (DRF) combines deep learning and random forest techniques, offering similar accuracy and interpretability as deep neural networks (DNNs) while being computationally efficient for edge intelligence tasks.
- The main challenge in accelerating DRFs lies in executing branch-split operations at decision nodes, which is crucial for improving performance.
- This study introduces a new DRF implementation using ferroelectric analog content addressable memory (ACAM) that enhances energy efficiency and latency, achieving significant improvements over existing DRF hardware on CPUs and ReRAM.
Objectives: This study assessed the content of US Medical Licensing Examination question banks with regard to out-of-hospital births and whether the questions aligned with current evidence.
Methods: Three question banks were searched for key words regarding out-of-hospital births. A thematic analysis was then utilized to analyze the results.