Particularities of Bone Regeneration in Rats after Implantation of Polycaprolactone Scaffold Mineralized with Vaterite with Adsorbed Tannic Acid.

We studied the particularities of osteo- and angiogenesis in albino rats after implantation of polycaprolactone scaffolds mineralized with vaterite with adsorbed tannic acid in the femoral bone defect. It was found that the processes of angio- and osteogenesis in the bone tissue after scaffolds implantation depend on their biocompatibility. Implantation of non-biocompatible scaffolds was followed by activation of angio- and osteogenesis aimed at separation of these scaffold from surrounding tissues.

Hybrid PCL/CaCO scaffolds with capabilities of carrying biologically active molecules: Synthesis, loading and in vivo applications.

Designing advanced biomaterials for tissue regeneration with drug delivery and release functionalities remains a challenge in regenerative medicine. In this research, we have developed novel composite scaffolds based on polymeric polycaprolactone fibers coated with porous calcium carbonate structures (PCL/CaCO) for tissue engineering and have shown their drug delivery and release in rats. In vivo biocompatibility tests of PCL/CaCO scaffolds were complemented with in vivo drug release study, where tannic acid (TA) was used as a model drug.

Influence of the electrolyte's pH on the properties of electrochemically deposited hydroxyapatite coating on additively manufactured Ti64 alloy.

Properties of the hydroxyapatite obtained by electrochemical assisted deposition (ED) are dependent on several factors including deposition temperature, electrolyte pH and concentrations, applied potential. All of these factors directly influence the morphology, stoichiometry, crystallinity, electrochemical behaviour, and particularly the coating thickness. Coating structure together with surface micro- and nano-scale topography significantly influence early stages of the implant bio-integration.

STRUCTURAL CHARACTERISTICS OF HUMAN AND OTHER MAMMALIAN ENDOTHELIAL CELLS.

Endothelial cells perform a number of important functions in the organism, and their dysfunction plays an important role in pathogenesis of a wide range of diseases. This review deals with the current literature data on structural characteristics of endothelial cells. A special section is devoted to endothelial cells development and differentiation.