Publications by authors named "M O Gallinari"
This study evaluated the bioactive potential of a macro-porous chitosan scaffold incorporated with calcium hydroxide (CH-Ca) and functionalized with bioactive doses of simvastatin (SV) for bone tissue regeneration. Initially, the bioactive dose of SV in osteoblastic cells (SAOS-2) was determined. For the direct contact experiment, SAOS-2 cells were plated on scaffolds to assess cell viability and osteogenic differentiation.
View Article and Find Full Text PDFDiatoms play a key role in the marine silica cycle, but recent studies have shown that sponges can also have an important effect on this dynamic. They accumulate large stocks of biogenic silica within their bodies over long periods, which are thought to vary little on an intra-annual scale. The observation of an abrupt decline in sponge biomass in parallel with large increases in abundance of a spongivorous nudibranch (Doris verrucosa) led us to conduct a year-long study on the effect of nudibranch predation on the silicon budget of a sponge (Hymeniacidon perlevis) population.
View Article and Find Full Text PDFArticle Synopsis
- 3D-printed resins are gaining popularity for temporary dental restorations, but their effects on oral tissue compatibility are not well understood.
- The study aimed to assess how different postpolymerization times impact the toxicity of these resins, using a model simulating oral tissue.
- Findings showed that shorter postpolymerization times significantly reduced the viability and metabolism of oral cells, while longer times allowed partial recovery, indicating a relationship between curing duration and cytotoxic effects.
This paper aimed to assess the influence of adhesive restoration interface on the diffusion of hydrogen peroxide (H2O2), indirect toxicity, and pro-inflammatory mediators expression by odontoblast-like cells, after in-office tooth whitening. Dental cavities prepared in bovine enamel/dentin discs were adhesively restored and subjected or not to hydrolytic degradation (HD). A whitening gel with 35% H2O2 (WG) was applied for 45 min onto restored and non-restored specimens adapted to artificial pulp chambers giving rise to the groups: SD- intact discs (control); SD/HP- whitened intact discs; RT/HP- restored and whitened discs; and RT/HD/HP- restored and whitened discs subjected to HD.
View Article and Find Full Text PDFMineral-induced bubbling effect and biomineralization as strategies to create highly porous and bioactive scaffolds for dentin tissue engineering.
J Biomed Mater Res B Appl Biomater
August 2022
Article Synopsis
- - The study evaluated chitosan-based scaffolds modified with mineral phases for their potential use in dentin regeneration, using a method that involved creating porous structures and biomineralizing them in simulated body fluid (SBF).
- - Various mineral compounds, like calcium hydroxide and nanohydroxyapatite, were added to chitosan to create three different types of scaffolds, enhancing their physical properties and promoting biomimetic conditions for dental tissue engineering.
- - Results showed that these mineral-enriched scaffolds, particularly CHCa and CHnHA, supported cell growth and led to significant increases in mineralized matrix formation, demonstrating their promise as effective biomaterials for dental applications.