transmission based on merozoite surface protein 1 () and 2 () gene diversity and antibody responses in Ibadan, Nigeria.

Background: Nigeria is a major contributor to the global malaria burden. The genetic diversity of malaria parasite populations as well as antibody responses of individuals in affected areas against antigens of the parasite can reveal the transmission intensity, a key information required to control the disease. This work was carried out to determine the allelic frequency of highly polymorphic genes and antibody responses against schizont crude antigens in an area of Ibadan, Nigeria.

Natural Perylenequinone Compounds as Potent Inhibitors of Glutathione S-Transferase.

The existing treatment strategy for Schistosomiasis centers on praziquantel, a single drug, but its effectiveness is limited due to resistance and lack of preventive benefits. Thus, there is an urgent need for novel antischistosomal agents. glutathione S-transferase (GST) is an essential parasite enzyme, with a high potential for targeted drug discovery.

Prevalence of and among patients with periodontal disease attending Dental Clinic, University College Hospital, Ibadan.

Background: Periodontal disease is often caused by bacterial plaque. However, there are indications that some infective agents, including parasites, may play important roles in the pathogenesis of the disease.

Aim: This study aimed at assessing the prevalence of gingivitis and periodontitis, as well as the prevalence of and , in the oral biofilm of individuals with periodontal diseases using polymerase chain reaction.

Computational Screening of Approved Drugs for Inhibition of the Antibiotic Resistance Gene in Methicillin-Resistant (MRSA) Strains.

Antibiotic resistance is a critical problem that results in a high morbidity and mortality rate. The process of discovering new chemotherapy and antibiotics is challenging, expensive, and time-consuming, with only a few getting approved for clinical use. Therefore, screening already-approved drugs to combat pathogens such as bacteria that cause serious infections in humans and animals is highly encouraged.

Insights from the shotgun-based proteomics analysis of Biomphalaria glabrata.

Biomphalaria glabrata is an important host in the transmission of human schistosomiasis in the Caribbean and South America. Therefore, it is of interest to analyse the proteome data of Biomphalaria glabrata hemolymph to identify immunity related proteins in host-pathogen relationship. We used shotgun proteomic and bioinformatic analyses of the non-depleted and depleted [0.