Publications by authors named "M O Brophy"
Background: Cancer-associated thrombosis (CAT) is a leading cause of death in patients diagnosed with cancer. However, pharmacologic thromboprophylaxis use in cancer patients must be carefully evaluated due to a 2-fold increased risk of experiencing a major bleeding event within this population. The electronic health record CAT (EHR-CAT) risk assessment model (RAM) was recently developed, and reports improved performance over the widely used Khorana score.
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- Older adults, who generally have multiple chronic conditions, make up a significant portion of patients with advanced non-small cell lung cancer (NSCLC), but their comorbidities are often poorly understood due to limitations in current assessment methods.
- The study aimed to identify and analyze patterns of multimorbidity in veterans treated for advanced NSCLC from 2002 to 2020, examining their relationship with mortality and healthcare usage.
- Five distinct multimorbidity patterns were identified, with variations in overall survival rates; certain patterns like metabolic diseases and cardiovascular disease were linked to a higher risk of death compared to those with more common aging conditions.
Bone marrow microenvironment plays an important role in promoting growth and survival of multiple myeloma (MM) cells. The tumor-promoting immune microenvironment is augmented while antitumor immune responses are inhibited. Although clinical and genomic markers of high-risk MM have been described, the immune status is just being recognized as a potential mediator of disease behavior.
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