Assessing a 12-month course of oral alendronate for adults with avascular necrosis of the hip: MANTIS RCT with internal pilot.

Background: People with avascular necrosis of the hip have very limited treatment options currently available to stop the progression of this disease; this often results in the need for a hip replacement. There is some weak evidence that a class of drugs called bisphosphonates may delay the course of the disease, and this trial was commissioned and set up to provide robust evidence regarding the use of bisphosphonates in adults aged ≥ 18 years with this condition.

Objectives: The aim of the Managing Avascular Necrosis Treatments: an Interventional Study ( MANTIS ) trial was to evaluate the clinical effectiveness and cost-effectiveness of a 12-month course of alendronate in the treatment of avascular necrosis.

An Epidemiological Analysis of the Recipients of the First Dose of the First Phase of COVID-19 Vaccination in Oyo State, South-Western Nigeria.

Background: Millions of people across the globe have been infected with coronavirus disease (COVID-19), and many lives have been lost in the process. As a result, vaccines are being developed to protect people from COVID-19 morbidity and mortality. Therefore, this study was conducted to assess the coverage rate for the COVID-19 vaccine in Oyo State.

Single-cell O exchange imaging shows that cytoplasmic diffusion is a dominant barrier to efficient gas transport in red blood cells.

Disorders of oxygen transport are commonly attributed to inadequate carrying capacity (anemia) but may also relate to inefficient gas exchange by red blood cells (RBCs), a process that is poorly characterized yet assumed to be rapid. Without direct measurements of gas exchange at the single-cell level, the barriers to O transport and their relationship with hematological disorders remain ill defined. We developed a method to track the flow of O in individual RBCs by combining ultrarapid solution switching (to manipulate gas tension) with single-cell O saturation fluorescence microscopy.

[Rare location of tuberculosis: endometrial tuberculosis].

Tuberculosis is a public health problem, especially in the developing countries. Bacillary pulmonary tuberculosis is the most common form of tuberculosis while genital tuberculosis is rare and underdiagnosed. We here report a case of endometrial tuberculosis.