Publications by authors named "M O Agbo"
Background: Multidrug resistance in Staphylococcus aureus continues to influence treatment complications in clinical settings globally. Multidrug-resistant-S. aureus (MDR-SA) is often genetically driven by resistance markers transferable in pathogenic strains.
View Article and Find Full Text PDFBackground: is an important nosocomial pathogen with increasing resistance to antibiotics. Objective: This study was performed to evaluate the genetic relatedness of MDR clinical isolates of .
Method: A total of 1000 samples were analysed in the study.
With the rise in antimicrobial resistance, there is an urgent need for new classes of antibiotic with which to treat infectious disease. Marinomycin, a polyene antibiotic from a marine microbe, has been shown capable of killing methicillin-resistant (MRSA) and vancomycin-resistant (VREF), as well as having promising activity against melanoma. An attractive solution to the photoprotection of this antibiotic has been demonstrated.
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- Melanoma and nonmelanoma skin cancers are leading forms of skin cancer, prompting research for new anticancer compounds through in vitro assays and in-silico methods.
- Screening of a small library of previously prepared compounds revealed 35 that inhibited the growth of skin cancer cell lines, particularly showing strong effects on A431 and SCC-12 cells.
- The most effective compounds (11 and 13) induced apoptosis and disrupted cancer-promoting pathways, suggesting potential targets for further study and development in treating skin cancers.
Background: Tuberculosis (TB) remains a global public health problem, with developing countries bearing the highest burden. Nigeria is first in Africa and sixth in the world among the countries with the highest TB burden, but is among the 10 countries accounting for over 70% of the global gap in TB case detection and notification. Enugu State, Nigeria reportedly has a notification gap of almost 14,000 TB cases; a situation which must be addressed.
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