Specific Antibodies and Arachidonic Acid Mediate the Protection Induced by the Cysteine Peptidase-Based Vaccine in Mice.

Several reports have documented the reproducible and considerable efficacy of the cysteine peptidase-based schistosomiasis vaccine in the protection of mice and hamsters against infection with and , respectively. Here, we attempt to identify and define the protection mechanism(s) of the vaccine in the outbred CD-1 mice- model. Mice were percutaneously exposed to cercariae following immunization twice with 0 or 10 μg recombinant cathepsin B1 (SmCB1) or L3 (SmCL3).

Does Curcumin Have a Role in the Interaction between Gut Microbiota and in Mice?

There is strong correlation between changes in abundance of specific bacterial species and several diseases including schistosomiasis. Several studies have described therapeutic effects of curcumin (CUR) which may arise from its regulative effects on intestinal microbiota. Thus, we examined the impact of CUR on the diversity of intestinal microbiota with/without infection by cercariae for 56 days.

Role of T lymphocytes and papain enzymatic activity in the protection induced by the cysteine protease against in mice.

Papain, an experimental model protease, was used to decipher the protective mechanism(s) of the cysteine peptidase-based schistosomiasis vaccine. To examine the role of T lymphocytes, athymic nude (nu/nu) and immunocompetent haired (nu/+) mice were subcutaneously (sc) injected with 50 µg active papain two days before percutaneous exposure to 100 cercariae of . Highly significant ( < 0.

In vitro effect of curcumin on Schistosoma species viability, tegument ultrastructure and egg hatchability.

Schistosomiasis remains a severe problem of public health in developing countries. The development of resistance to praziquantel (PZQ) has justified the search for new alternative chemotherapies with new formulations, more effective, and without adverse effects. Curcumin (CUR), the major phenolic compound present in rhizome of turmeric (Curcuma longa L.